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KMID : 0356720030190060372
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Journal of the Korean Society of Coloproctology
2003 Volume.19 No. 6 p.372 ~ p.378
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Clinical Value of the Change in the Serum Carcinoembryonic Antigen (CEA) Level after Curative Surgery in Colorectal Cancer
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Kim Young-Hoon
Bae Byung-Noe
Kim Ki-Whan
Han Se-Hwan
Kim Hong-Joo
Kim Young-Duck
Kim Hong-Yong
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Abstract
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Purpose: This retrospective study was designed to evaluate the clinical value of changes in the serum carcinoembryonic antigen (CEA) level after curative surgery in colorectal cancer patients.
Methods: The clinical value of preoperative serum CEA and dCEA (postoperative 7-day CEA/preoperative CEA) in 115 patients with colorectal cancer, who underwent curative surgery at our Department of General Surgery from 1994 to 1997, was investigated.
Results: The preoperative CEA level was significantly associated with histologic differentiation (P=0.035) and reccurence (P=0.044), but not gender, tumor size, lymph node metastases, Duke´s stage, and vascular invasion. dCEA was significantly associated with lymph-node metastases (P=0.017), histologic differentiation (P=0.024), Duke´s stage (P=0.021), recurrence (P=0.008), and survival rate (P=0.0379). Especially, in the abnormal preoperative CEA level (＞5 ng/mL) group, if dCEA was more than 0.5, these patients had a very poor prognosis (P=0.0003).
Conclusions: dCEA was associated with more clinicopathologic prognostic factors than preoperative CEA, especially with survival rate. Therefore, we expect dCEA to be a more useful tool for predicting patient outcome. J Korean Soc Coloproctol 2003;19:372-378
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KEYWORD
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Carcinoembryonic antigen/blood, Colorectal neoplasms, Tumor markers, Biological
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